Herb-St Johns Wort

Numerous studies have shown that St. John’s wort is a safe and effective natural herb for depression. It’s typically used for moderate depression.

A 2017 review article summarizing 27 studies compared St. John’s wort and Selective serotonin reuptake inhibitors (SSRIs) in a participant pool of 3,808. SSRIs are common antidepressant drugs that are often prescribed for those with depression disorders. The studies found that St. John’s wort was as effective as SSRIs in treating depressive symptoms. 

In a double-blind study, St. John’s wort extract was compared to fluoxetine (an SSRI) in a group of elderly subjects with mild-to-moderate depression. Researchers found that St. John’s wort was just as effective as fluoxetine and elicited no adverse effects on cognitive performance. 

Another clinical trial comparing St. John’s wort extract to imipramine (an antidepressant drug) found that both treatments were effective in improving the quality of life in subjects with depression. Although they were comparable, St. John’s wort was found to be better tolerated among participants. 

Two different types of St. John’s wort extract were examined in another double-blind study. Researchers discovered that the content level of hyperforin, the primary chemical component in St. John’s wort, was responsible for the effectiveness of the extract. The higher the hyperforin content, the more effective the extract was found to be.

In a trial observing those with depression, St. John’s wort extract was found to be effective for treating mild-to-moderate forms of depression. However, the extract was found to not be helpful for those suffering from major depression. 

The Commission E, a German government health agency, mentions that St. John’s wort is appropriate to use in cases of depressive moods, anxiety, and nervous unrest.

The European Scientific Cooperative on Phytotherapy (ESCOP) also reports that St. John’s wort is useful for mild-to-moderate depressive states, restlessness, anxiety, and irritability. 

Summary:
Research shows that St. John’s wort is a beneficial herb for moderate depression.

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